The human genome sequence has been a breakthrough for modern biology, a milestone similar to the discovery of the structure of the DNA chain or by the assumption that each gene codes for a protein. Despite its importance, and our current view of biology, these data are static. So today we take into account many more elements to understand the process of differentiation and functional specialization of cells with the same genome. One approach is to look at the result of the expression of the genome, ie proteins that are synthesized from the information contained in DNA. This level of analysis gives us a dynamic view on how much of the genetic information is expressed in the cell at a given time. Furthermore, it is a higher level, that of functional protections: when there is a change in the environment, our genome remains unchanged, while our protease can be modified to preserve the physiological properties of cells .

The proteins, once synthesized, are modified by the attachment of other molecules in a stable or unstable, which can radically alter the final biological activity of the protein. The post-transcriptional modification (RNA editing) and post translational (phosphorescent, constellation, adulation and cleavage, etc.) Allow for protein biological activity very different part of the same gene. This overview is attached to the modeling of phenomena of structural conformation of proteins and their multiple interactions at different levels, offer a global map of the molecular dynamics of proteins in the work discussed below.