Research in the past eight years has driven the classical idea that nuclear processes occurring from transcriptional activation to the mature mRNA out of the nucleus were independent events. The work of many groups has contributed significantly to turning...
The export of messenger RNA from nucleus to cytoplasm is an essential process in eukaryotic cells. Sus1 protein plays a significant role in the coupling between the initiation of transcription and mRNA export. Sus1 is a small protein (11kDa of only),...
Several themes are featured. Transcriptional activators bind to specific DNA sequences, and the chromatin context of the DNA biding site can have a positive or negative influence on binding of the activator or the proteins it recruits to the promoter....
Viroids are the bottom rung of the biological scale, being exclusively composed of a small circular RNA of 250-400 nucleotides lacking any coding capacity, a key aspect that differentiates them from the viruses that encode proteins themselves. Virus and...
For the first time described the role of a protein kinase (GCN2, which normally acts as initiator of the translation factor in mammals) as a mediator in the early stages of cellular response to RNA virus infection. The work has been signed by a research...
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