Insulin is a paradigm of regulation and specific function. Essential anabolic hormone in the adult, seems to have a different role during embryonic development. A group from the Center for Biological Research, CSIC has been characterized step by step...
Procesos como el desarrollo embrionario, la angiogénesis, la cicatrización de heridas y la metástasis se basan en la migración celular, un complejo proceso regulado por múltiples rutas de señalización intracelular. Las integrinas y las GTPasas de...
The interaction between genomic regulatory elements (cis) and transcription factors (trans) is one of the main avenues for modulation of the transcriptome, while it deregulated in pathological conditions such as cancer. In turn, the repetitive genomic...
Since the middle of last century was known that in vertebrates, meiosis and early embryonic divisions required polyadenylation and translational activation of maternal mRNA stored in the oocyte. However, it was not until the nineties when it began to...
Failures in the replication of genetic material during cell division leads to the activation of the checkpoint (checkpoint) of replication, conserved in eukaryotes. When it detects replicative stress cellular responses are activated to preserve the...
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