One of the tenets associated with cancer advocates that the inactivation of oncogenes leads to remission of the tumors, implying that oncogenes would be the real Achilles heel of cancer. This model has kept the oncogenes as a therapeutic target clear and...
Sirtuins (SIRT), protein family of histone deacetylases (HDAC) are involved in processes such as longevity, cancer, gene regulation, energy homeostasis and apoptosis.Inhibitors of sirtuins have antitumor properties, but so far no known inhibitor, such...
If neurons use glucose for oxidative stress defense, then where do get the energy? Astrocytes, close neighboring neurons and cerebral microvessels, metabolize glucose very quickly that catch the blood. To this end, dependent protein kinase 5'-AMP (AMPK)...
The gene TARBP2 (TAR-RNA binding protein 2) is key to the production machinery of microRNA. These microRNAs are short strands of ribonucleic acid that regulate the intensity of the activity of other genes activated and deactivated, and active...
To most patients with cancer—and even to the physicians caring for them—the word "genomics" has little or no meaning. Many are vaguely aware that genomics has something to do with genes and may somehow relate to a genetic risk for cancer within...
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