Understanding the biology of aging and therapeutic approach to pathologies associated with its development are facilitated by the study of syndromes of accelerated aging or progeria. These syndromes are characterized by early onset of physiological...
Transcription is a process in eukaryotic cells is coupled to mRNA processing and transport. In recent years, we know that the transcription of at least a number of genes occurs at the nuclear periphery near the nuclear pore. In yeast ASaccharomyces...
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG triplet expansion, enabling long polyglutamine sequence in the huntingtin protein. The disease appears in about 40 years and presents with involuntary movements, rigidity...
Alzheimer's disease (AD) and other neurodegenerative processes are characterized by a deregulation of intracellular levels of neuronal Ca 2 +. This alteration seems to carry an implicit cause-effect relationship to toxicity by the β-amyloid peptide and...
The cell cycle progression is governed by a family of kinases (cdk: cyclin dependent kinases) whose activities are regulated by binding to regulatory subunits called cyclins. During the cell cycle and activate form specific pairs of cdk and cyclins. The...
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