Sirtuins (SIRT), protein family of histone deacetylases (HDAC) are involved in processes such as longevity, cancer, gene regulation, energy homeostasis and apoptosis.Inhibitors of sirtuins have antitumor properties, but so far no known inhibitor, such...
The mitochondrial protein BCL-2 family are critical in apoptosis. They are structurally related and can be classified as a functional and structural. Can be subdivided into multidomain proapoptotic proteins (such as BAX and BAK), multidomain antiapoptotic...
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