Subunit composition of Srb/Mediator-like complexes
In: Gene ExpressionSubunit composition of Srb/Mediator-like complexes
The subunits of yeast, human and mouse SRB/mediator-like complexes are compared. Identical or orthologous subunits are marked by tan boxes and connected by lines. Numbers indicate subunit size in kDa. Soh1 has not yet been confirmed as a component of the yeast Srb/Mediator.
| Yeast | Human | Mouse | ||||||||||||||
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| SRB/ Mediator |
TRAP/ SMCC |
DRIP | ARC | CRSP | NAT | hMED | mMed | Notes | ||||||||
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| 240 | |
250 | |
250 |
| Srb8 | 230 |
| 230 | |
240 | |
240 |
| Srb9 | 160a |
| Nut1 | 160b |
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220 | |
205 | |
205 | |
200 | TRAP220 binds hormone receptors |
| Rgr1 | |
170 | |
150 | |
150 | |
150 | |
150 | |
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110 | Human Rgr1, also called EXLM1 |
| 150a | 140 |
| Gal11 |
| 150b | |
130 | |
130 | |
130 | |
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|
Sur2 | hSur2 interacts w/E1A & VP16 |
| 105 | ARC105, also called TIG1 |
| 100 | |
100 | |
100 | |
100 |
| Sin4 |
| 97 | 97 | 95 | 96a |
| 95 | |
92 | |
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96b |
| Srb4 |
| 93 | 92 | 85 | 90 |
| 80 | |
77 | |
77 | |
77 | |
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78 | TRAP80 interacts w/ VP16, p53 |
| 78 |
| 70 | |
70 | |
70 | DRIP/ARC/CRSP70 similar to TFIIS |
| Med1 | 70 |
| Srb10 | |
Cdk8 | |
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Cdk8 | |
Cdk8 | CTD kinase activity |
| Med2 | 45 | 45 |
| Pgd1 | 37 |
| 37 | |
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34 |
| Srb5 |
| 36/28 | |
36 | |
36 | |
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34 |
| Med7 | |
hMed7 | |
34 | |
34 | |
33 | |
hMed7 | |
hMed7 | |
mMed7 |
| Srb11 | |
cyclin C | |
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cyclin C | |
cyclin C | Cyclin partner of Srb10/Cdk8 |
| Med6 | |
hMed6 | |
33 | |
33 | |
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mMed6 | Involved in activation in yeast |
| TRFP | |
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TRFP | Homolog of TRF-prox. protein |
| Med4 | 30 |
| Med8 | 32 | 28b |
| 24 | 23 |
| Rox3 |
| 22 | 22 |
| Srb2 | 21 |
| Srb7 | |
hSrb7 | |
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hSrb7 | |
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mSrb7 | Essential in yeast and mouse |
| Soh1 | |
hSoh1 |
| Nut2 | |
hNut2 | |
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hNut2 |
| Cse2 |
| 12 |
| Med11 |
| Srb6 |