NEW
HAVEN, September 27, 2001/– Molecular Staging Inc.
(MSI) announced today that it has been awarded two
additional patents for Rolling Circle Amplification
Technology (RCAT^TM).

This further expands the
intellectual property estate surrounding MSI’s Rolling
Circle Amplification Technology to a total of 11 issued
patents, including eight U.S. patents and three
international patents.

Rolling Circle
Amplification Technology detects and measures proteins as
well as nucleic acids with unprecedented sensitivity and
expanded multiplexing capabilities.

Patent number 6,287,824
for “Molecular cloning using rolling circle
amplification” was issued September 11, 2001.  This application of Rolling Circle Amplification Technology
enables scientists to clone DNA without using biological
host organisms such as bacteria, viruses or yeast cells. 
The outcome is cloned DNA with far greater coverage
than is possible with methods which need to use a
biological host.  Patent
number 6,291,187 for “Polyprimed amplification of
nucleic acid sequences,” which was issued September 18,
2001, relates to further enhancements of the significant
sensitivity advantages enabled by Rolling Circle
Amplification Technology.

In other patent news,
the company was also awarded patent number 6,287,825,
“Methods for reducing the complexity of DNA
sequences,” on September 11, 2001. 
This patent adds to the Company’s existing patent
portfolio on Allele Frequency Distortion (AFD), another of
MSI’s proprietary technologies.

MSI is a life science
company developing a portfolio of technologies for
detection and measurement of proteins and nucleic acids
across a broad range of applications, including proteomics,
genomics, pharmacogenomics and diagnostics. 
One of MSI’s core technologies is Rolling Circle
Amplification Technology (RCAT^TM),
a proprietary amplification process that has significant
advantages in terms of sensitivity, multiplexing, dynamic
range and scalability. 
Additional information about MSI can be found at www.molecularstaging.com

CONTACT:                                  

Molecular
Staging, Inc.

                          
Jennifer Joiner, 203/772-5000