A group from the National Center for Biotechnology AMBO publishes a review of the role of fosfoinosítido3-kinase (PI3K) in the processes of cell division. This is an interesting article that summarizes the different key points of mitosis in acting in the PI3K decisive.

This kinase is active in the initiation of cell division through two main routes. First, the activation of PI3K by early signals induced by growth factors, promotes the onset of cell cycle and cell growth. The other course of action of PI3K in the initial stages of the division is the inactivation of Fox factors (Forkhead box, subgroup O), responsible for inducing the expression of genes during the G0 quiescence. Finally, PI3K is also responsible for precise regulation of late stages of cell division.

This study allows to update much of the preparatory work carried out in this line of research and detail the key processes in which PI3K is involved. Besides the already mentioned observations on the regulation of cell cycle, it is important to emphasize the role of different mutations in the PI3K oncogenic activity as inducers of cell migration and malignant transformation, in addition to involvement in the immune response of different is forms subunits of the enzyme.

Multiple points of regulation in which PI3K plays a role makes this kinase an enzyme particularly interesting to study in reference to the possible impact of their mutations and is forms in the onset of tumors in humans. The ultimate goal of this research would be to obtain basic information to advance cancer therapy.