In liquid phase hybridization, HPV probe and target are in solution. The liquid-phase hybridization was used to estimate the genetic relationship among different HPVs, today is of little use.

The hybrid capture system also comes amid the specimen is denatured líquido.Primero then HPV DNA is hybridized with the corresponding probe. The hybrids are captured by the receptacle, covered with anti-hybrid antibodies that react with alkaline phosphatase, becoming visible after the application of a chemiluminescent substrate. The uptake of hybrid systems are still in experimental phase, initial tests can involve highly sensitive and easy technique. IN LIQUID PHASE