The XXVII Congress of the SEBBM (Lleida, September 2004), authors who have signed this collaboration between universities in the Basque Country and Victoria (Canada) presented his studies on the interaction of nucleoplasmin with chromatin early somatic after fertilization of the oocyte. Nucleoplasmin, first described as a molecular chaperone protein (for RA Lackey in 1978) is an acidic protein of the oocytes whose activity is regulated by phosphorylation. 

Its main function is decongested sperm chromatin after fertilization, by removing proteins, and chromatin remodeling of the sperm nuclear somatic, promoting the assembly of nucleosomes, a process described in detail in Venous leaves, which is the main chaperone function This pantomimic protein. The nucleoside remodeling involves the deposition of the his tone octane, a process which the authors of this paper have proposed a model of its own, consisting of the nucleoplasmin presence of two surfaces for interaction with different proteins involved.

Now, the same teams who have worked on this model show that the highly phosphorylated nucleoplasmin from Venous leaves oocyte sperm chromatin can be deployed and somatic chromosomal proteins by removing the spacer DNA regions without a stable interaction with the nucleoside. The results presented are discussed, taking into account the possible involvement of nucleoplasmin, as suggested in the literature, in processes such as transcription and replication license that occur after fertilization of eggs, early development.