To most patients with cancer—and even to the physicians caring for them—the word "genomics" has little or no meaning. Many are vaguely aware that genomics has something to do with genes and may somehow relate to a genetic risk for cancer within...
To maintain genomic stability, mammalian cells require the action of five proteins encoded by paralogous genes to that of RAD51, a molecule involved in DNA repair, implying orquesrado operation of certain protective mechanisms. In previous work on...
Insulin is a paradigm of regulation and specific function. Essential anabolic hormone in the adult, seems to have a different role during embryonic development. A group from the Center for Biological Research, CSIC has been characterized step by step...
The TAP (tissue plasminogen activator) is the main converter of plasminogen to plasmin in the brain, where it seems to have a beneficial role. In fact, it has been used as a drug to reduce brain damage in patients who have suffered strokes, as in...
Failures in the replication of genetic material during cell division leads to the activation of the checkpoint (checkpoint) of replication, conserved in eukaryotes. When it detects replicative stress cellular responses are activated to preserve the...
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