Archive for the ‘Gene Expression’ Category

Transcription Initiation Apparatus We discovered that the RNA polymerase II transcription initiation apparatus contains a multiprotein complex, called the Srb/mediator complex, which is involved in mediating the response to...

Subunit composition of Srb/Mediator-like complexes The subunits of yeast, human and mouse SRB/mediator-like complexes are compared. Identical or orthologous subunits are marked by tan boxes and connected by lines. Numbers indicate subunit size in...

Several themes are featured. Transcriptional activators bind to specific DNA sequences, and the chromatin context of the DNA biding site can have a positive or negative influence on binding of the activator or the proteins it recruits to the promoter....

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