Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG triplet expansion, enabling long polyglutamine sequence in the huntingtin protein. The disease appears in about 40 years and presents with involuntary movements, rigidity...
The control of gene expression depends on the access of chromatin gene regulatory areas to the transcriptional machinery. The covalent modifications of histones as acetulaciones and methylation are key factors to regulate that access. Reading the...
In the laboratory of Fernando Rodriguez Pascual, Researcher, Center for Biological Research of the CSIC, are very interested in studying mechanisms regulating gene expression vasoconstrictor peptide endothelin-1 (ET-1) at both transcriptional and...
Alzheimer's disease (AD) and other neurodegenerative processes are characterized by a deregulation of intracellular levels of neuronal Ca 2 +. This alteration seems to carry an implicit cause-effect relationship to toxicity by the β-amyloid peptide and...
One of the tenets associated with cancer advocates that the inactivation of oncogenes leads to remission of the tumors, implying that oncogenes would be the real Achilles heel of cancer. This model has kept the oncogenes as a therapeutic target clear and...
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