The gene hedgehog (hh) was initially identified as a key gene in embryonic development of the fruit fly, Drosophila melanogaster. While Drosophila has only one hedgehog gene, vertebrates have three peers. These proteins are secreted extracellular ligands by a group of cells during organ formation in the embryo. In the adult hedgehog maintains and regulates stem cells in many tissues, being instrumental in regenerative processes. There is also a close relation between HH signaling pathway and the development of tumors, genetic alterations observed that stimulate the growth of tumor cells in the digestive tract, lung and prostate .

• Tags: carcinogénesis, Molecular, receiver